Hey @Ben - I am no ageing research veteran but have seen a fair amount of high-throughput screens (CRISPR and small molecule). Strategically, I think we should look for processes that are (I) highly automatable, (II) specific/relevant to the ageing field (III) benefit from (or at least not in conflict with) the DAO structure. With these 3 desiderata, I am thinking about both wetlab and dry-lab methods. For example a set of well-maintained bioinformatics platforms for seq alignment, RNA-seq etc. Users pay with crypto instead of maintaining their own infrastructure or building it up from the ground via AWS.
A couple (pet) projects I was planning to work on in the past that might get some creative juices flowing:
- integrated Horvath clock analysis: send us the sample and we run the methylation array with integrated analysis. The whole pipeline is transparent. Results and metadata are stored in our data vault. We could charge for the analysis and rent out some of the data as well possibly.
- decentralized nanopore sequencing (I was primarily thinking about a ChainLink datastream for viruses in waste water - maybe we can find something relevant for ageing as well)
- screening as a service (huge overhead)
- decentralized clinical trials (volunteers across the world participate in a clinical trial network for ageing and receive Vita tokens. We have a platform clinical trial protocol, in which new drugs get phased in and phased out dynamically based on a surrogate endpoint (e.g. Horvath clock of leukocytes after every month), overall survival as the secondary endoint. VitaDAO acts as the owner of the clinical trial network - we collect data from participants and ensure logistics (with partners if necessary). Networks need to purchase Vita (or some other token) to pay trial participants and data collection services. This is also a gargantuan project idea.
Probably we should create a document to systematically collect ideas within the working group to come up with a useful (valuable vs. achievable 2x2 matrix) of core services.