VDP-139 [Funding] Luminova: mtON gene therapy in the aged eye One-liner: Rejuvenating mitochondrial function by harnessing the power of light Longevity Dealflow WG team Senior Reviewers: Project has been evaluated by 4 reviewers: 3 academia and 1 biotech Shepherd: Maria Marinova, Jason Mercurio Ot…

@michele.gallia I agree with @Shahaf here. 30% effect size is the very first attempts. If you’ve done science, you know that many big phenotypes are the result of tons of trial error. Moonshots by definition are things that are extremely hard to do, so one wouldn’t expect to land on the moon on the …

Thank you Tim for your contribution to the discussion. Here are my two cents The tweet refers to a 7% effect in mice, not in worms so it is not comparable. I do not know of any therapy that has a bigger effect on mice than on worms for the simple reason that mice are much more complex than worms…

@Shahaf Thank you Shahaf for your answers to my questions and I will make sure to read the paper you mention. Here are a few initial thoughts I would argue that worms are not the best model for any disease in humans you are proposing mTON + ATR + light + an additional therapy - the odds of ha…

[image] michele.gallia: Here is an example of a research with decent results in worms >100% effect I’m aware. We are making two different points. My point is about not conflating today’s capabilities with tomorrow’s possibilities ( ref ). Those that invested in reprogramming and numerous other …

I understand, and my point is: Given today’s capabilities, tomorrow’s possibilities are bleak for this research :wink:

Also, a way more advanced company seems to be doing something that looks very similar GenSight Biologics , is developing a pipeline of therapies using mitochondrial targeting sequence and optogenetics technologies to address retinal diseases and central nervous system disorders. [image] Ge…

[image] Shahaf: So the effect in T-cells is not ‘insignificant’ - at least based on preliminary data. Based on that paper, I’m inclined to disagree. The increase in CD8 killing of EL4 cells was minimal. It’s also not clear that there aren’t more mitochondria vs more effective ones, nor that i…

VEGF sounds good to me! And it’s approved.

[image] m_marinova: In the process of collecting reviews. Votes should be reset and only allowed to vote once senior review is completed. Otherwise not valid.

VDP-139 [Funding] Luminova: mtON gene therapy in the aged eye

Proposals

vincent March 5, 2024, 5:51pm 35

Very exciting research proposal!! And helpful conversation!

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VDP-139 [Funding] Luminova: mtON gene therapy in the aged eye

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