# Longevity biomarkers review article + bounty **URL:** \ **Category:** General\ **Created:** [June 21, 2022, 2:17pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735 "2022-06-21T14:17:04Z")\ **Posts on this page:** 20\ **Page:** 2
**Author:** ![strygah](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/strygah/32/273_2.png) [@strygah](https://gov.vitadao.com/u/strygah)\ **Post date:** [July 10, 2022, 1:57pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/21 "2022-07-10T13:57:59Z")
Here is the [Google Doc] with @bowtiedshrike 's skeleton ([Longevity Biomarkers Draft - Google Docs](https://docs.google.com/document/d/1G7TeDOgfP7xw1ihDefl76CspU026oRb6JdQHElBAJn8/edit?usp=sharing)) I propose working inside this doc. It is currently opened for editing for everyone, please let me know if I should restrict the access. 17 July is fine for me ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [July 10, 2022, 3:25pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/22 "2022-07-10T15:25:50Z")
I see what you mean. If a p-value went from 0.001 to 0.01, the ratio would “worsen”, but it could happen by chance alone and tell nothing about the biomarker’s predictive power. Let’s see if I can put in additional variables and find a workaround to this problem. But it’s on the back-burner for now. Regarding the review, I like some markers more than others. I would like to write on physiological markers – functional, like gait speed, grip strength, and anatomical, like markers of vascular health. Skin autofluorescence and few others too. Additionally, I can write on laboratory blood markers. I wonder if @strygah might want to trade markers with me (physiologic markers for age clocks). One more thing. Due to prior commitments, I won’t be able to start writing before the beginning of August. ---
**Author:** ![strygah](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/strygah/32/273_2.png) [@strygah](https://gov.vitadao.com/u/strygah)\ **Post date:** [July 11, 2022, 5:44am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/23 "2022-07-11T05:44:47Z")
I can, though I am less qualified in age clocks. Probably even better idea would be for me to do both (age clocks and physiological), and then @rpill will add depth to both as well in August? ---
**Author:** ![strygah](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/strygah/32/273_2.png) [@strygah](https://gov.vitadao.com/u/strygah)\ **Post date:** [July 14, 2022, 4:49pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/24 "2022-07-14T16:49:26Z")
I am very sorry, I will not be able to hit the 17 July deadline, have unexpected (very bad) family issues and the time I planned to allocate to the review will need to be spent with family. 21-22 July should be viable for me though. ---
**Author:** ![bowtiedshrike](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/bowtiedshrike/32/227_2.png) [@bowtiedshrike](https://gov.vitadao.com/u/bowtiedshrike)\ **Post date:** [July 14, 2022, 11:19pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/25 "2022-07-14T23:19:09Z")
Given that rpill is delayed too, we can push the deadline back a week to July 24. Prayers for you and your family. ---
**Author:** ![longevion](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/longevion/32/675_2.png) [@longevion](https://gov.vitadao.com/u/longevion)\ **Post date:** [August 15, 2022, 10:13am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/26 "2022-08-15T10:13:01Z")
It seems like a nice squad has formed here. What do y’all propose as next steps and how can I facilitate and empower y’all? ---
**Author:** ![strygah](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/strygah/32/273_2.png) [@strygah](https://gov.vitadao.com/u/strygah)\ **Post date:** [August 15, 2022, 10:53am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/27 "2022-08-15T10:53:25Z")
I still owe a chapter, sorry for the delay. Death of a family member and moving to another country took a lot of time - still struggling with task overflow ---
**Author:** ![longevion](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/longevion/32/675_2.png) [@longevion](https://gov.vitadao.com/u/longevion)\ **Post date:** [August 15, 2022, 11:35am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/28 "2022-08-15T11:35:01Z")
Condolences 🤟 No worries and no rush at all 😊 ---
**Author:** ![bowtiedshrike](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/bowtiedshrike/32/227_2.png) [@bowtiedshrike](https://gov.vitadao.com/u/bowtiedshrike)\ **Post date:** [August 16, 2022, 3:58am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/29 "2022-08-16T03:58:49Z")
@strygah and @rpill would Labor Day (Sept 5) work as a target to have the first bits up? Would be great if @Derek and VictorB still want to be part of it, but once we get the first few parts done, we can just expand to fill in what people don’t do, and update the author list as needed based on contributions. For the first draft, this does not have to be the final product. First step is words on the page, and then we can refine from there. For example my part is very high level. Maybe we stay that way, maybe we polish it a lot more. ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [August 16, 2022, 6:26pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/30 "2022-08-16T18:26:27Z")
Hello! Yeah, my writing is long overdue. Okay, I will aim for September 5 to have my first draft. ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [September 6, 2022, 2:20pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/31 "2022-09-06T14:20:25Z")
Sorry, been caught up with outstanding tasks. My first draft will be done by the end of the week. ---
**Author:** ![strygah](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/strygah/32/273_2.png) [@strygah](https://gov.vitadao.com/u/strygah)\ **Post date:** [September 6, 2022, 2:36pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/32 "2022-09-06T14:36:41Z")
I’ve done some progress Now working on a comparison table ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [September 11, 2022, 5:45pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/33 "2022-09-11T17:45:01Z")
Hey! Here’s my bit. I still need to write about bloodwork panels and urine biomarkers, so the final text will be twice as long. Comments are open. > **[biomarkers](https://docs.google.com/document/d/143Cc4acHbHF7iWL8R7bw3nfcehKS1juEfeXyqpqG2CA/edit?usp=sharing)** > > Assessment of health and risk factors and their correlation with life- and healthspan have been employed to measure the efficacy of pharmacological and lifestyle interventions. Body fluids are routinely tested for a range of parameters to evaluate... ---
**Author:** ![bowtiedshrike](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/bowtiedshrike/32/227_2.png) [@bowtiedshrike](https://gov.vitadao.com/u/bowtiedshrike)\ **Post date:** [October 1, 2022, 4:12pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/34 "2022-10-01T16:12:10Z")
Added your part into the document @strygah set up. Looks like we still have panels, clocks, comorbidities and neurologic markers in the outline, and would be good to flesh out phenotypic ones more. I will work on comorbidities. @rpill would you be able to do panels and neurologic markers, @strygah age clocks and phenotypic markers? October will be busier than Sept for me, but let’s see if we can get an initial draft of these by the end of Oct. ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [October 1, 2022, 5:18pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/35 "2022-10-01T17:18:30Z")
@bowtiedshrike Hello! Yes, I will finalize the panel bit. If no one joins us for the neurologic markers part, I can have a go at it too. ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [October 2, 2022, 10:02am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/36 "2022-10-02T10:02:57Z")
@InquilineKea Hey, Alex! Are you interested? ---
**Author:** ![vincent](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/vincent/32/93_2.png) [@vincent](https://gov.vitadao.com/u/vincent)\ **Post date:** [October 3, 2022, 5:41pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/37 "2022-10-03T17:41:38Z")
Excited about this, pinged Alex if he is interested to contribute… Bryans measurements are also an interesting reference > **[blueprint](https://blueprint.bryanjohnson.co/#step-3-measurements)** > > Cargo and the criteria he came up with: [Bam Criteria — blueprint](https://blueprint.bryanjohnson.co/Bam-Criteria) ---
**Author:** ![bowtiedshrike](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/bowtiedshrike/32/227_2.png) [@bowtiedshrike](https://gov.vitadao.com/u/bowtiedshrike)\ **Post date:** [October 4, 2022, 12:21am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/38 "2022-10-04T00:21:24Z")
I have mixed feelings on his criteria 5-7. On one hand, the whole purpose of a marker is just that it reports, not that it has any causality. On the other hand, people will try to game markers, and focus on ‘how do I make marker go down’ instead of ‘how do I improve longevity’. I also think he missed discussion of robustness and ease/cost for the markers. If it’s cheap and easy, it is scalable. If it’s robust it will take less interpretation. Way too many studies show a tiny change that is significant with stats wizardry and n = 10,000, and then ‘Factor X is involved in cancer/atherosclerosis/etc’. Or maybe this is what is behind points 5-7. ---
**Author:** ![evgenity](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/evgenity/32/354_2.png) [@evgenity](https://gov.vitadao.com/u/evgenity)\ **Post date:** [October 26, 2022, 6:19pm UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/39 "2022-10-26T18:19:22Z")
Hi, I would be happy to join and contribute. Please reply if you need any assistance. E.g. if you provide links to some articles I’ll be happy to summarise the results. ---
**Author:** ![rpill](https://dub1.discourse-cdn.com/flex017/user_avatar/gov.vitadao.com/rpill/32/979_2.png) [@rpill](https://gov.vitadao.com/u/rpill)\ **Post date:** [October 27, 2022, 2:54am UTC](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735/40 "2022-10-27T02:54:00Z")
Hi, @evgenity! The neurologic markers part is available. You’ll have to write it on your own – i.e. sieve through the literature and do a critical assessment. [Previous page](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735.md?page=1) [Next page](https://gov.vitadao.com/t/longevity-biomarkers-review-article-bounty/735.md?page=3)