Longevity biomarkers + 3000 $VITA review article bounty

Ok, let me give it a try. If someone volunteer to help me - i’d be grateful.
Can you provide a link (or screenshot) of the airtable?

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Hey, @evgenity! We have a Zotero library with all the relevant papers. We only have few on neurologic markers, but I can add more papers for you to work on. I will add you shortly (I have your email from your request to access my google file.)

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ResearchHub put up an additional 40,000 $RSC (ResearchHub Coins) bounty for this :slight_smile:

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What do you all think of using a knowledge graph to build out the overview of different biomarkers and their strengths and weaknesses, as well as to manage attributions of who contributed how much to this collective knowledge? We could use lateral.io for this, and collaborate with https://graphlab.addpotion.com/ (that we supported via LongevityPrize where VitaDAO is one of the contributors)

This could then be turned into a review article published in a decentralized way (also on researchhub) + video (with eleanor sheekey + vitadao) + on vitadaos web page potentially

This also ties into the The Longevity Prize on biomarkers btw for those interested to participate in it

I think we should try our DeSci options and attract more interested people. After we’ll have done several iterations on the whole pipeline – and once the result is really good – we can consider publishing the review traditionally. Thanks, Vincent! I’ll check the links you posted.

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yes absolutely agree, we can create multiple version, ideally we get to something interesting in say next 2-4 months.

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I think a knowledge graph is worth considering later on, or as one or more figures. First step is get a draft on paper. Then start refining the draft and deciding how in-depth this review will be.

I agree with @rpill that we should aim for publishing in a peer-reviewed journal as a review, which limits the length somewhat.

I’m digging out from my Oct, but hopefully will be caught up by next week.

If we can get the first review done, then we can worry about writing the 500-page longevity textbook one chapter at a time.

@evgenity welcome to the group! If you want to work on the neurologic markers, that would be great. Do you have a timeline for that section?

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I guess I need one week to gather materials and draft main ideas. And then another week to prepare a text.

Found a fresh article on a novel biomarker Unsupervised learning of aging principles from longitudinal data | Nature Communications

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Nov 19 will be the target date to get as much done.

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Hi, @evgenity! You’re an IT guy, right? I would assume writing on bloodwork panels and deep learning models is more in line with your expertise. So how about you write on panels then, and I take the neurologic markers? I’ve gotten some papers on panels in Zotero.

One way of finding new papers would be throwing them together on ResearchRabbit or a similar website and seeing what the algorithm suggests.

Hi, @rpill, sounds like a great idea, I’ll definitely take deep learning models and also try to deal with panels.

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Hi guys,
I just found my way here over from the longevity prize. This is a very nice initiative. I am a researcher in neuroscience and metascience with a fairly strong background in biomarker research. Would like to help. I think the most valuable contribution I can make is to help go over the text and propose edits for accuracy and clarity. Will start with some notes in the existing doc.

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Hi, @gustav_nilsonne! Would you be willing to write on neurologic markers? You’re better positioned to write on the topic given your background.

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Hi! Sorry, but my pile of overdue writing projects will take months to clear. Commenting on existing text, on the other hand, is something I can relatively easily fit in.

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Excited to have you here, welcome Gustav! Would be great to have you onboard as a reviewer

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Great initiative!
I would be happy to help with reviewing it.
My expertise is in epigenetic biomarkers of aging (e.g. https://www.biorxiv.org/content/10.1101/2022.06.03.494609v1.full)

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Got some text for co-morbidities up into Strygah’s document, and addressed some of Gustav’s comments there.

Looks like we still have age clocks and biomarker panels to add in. Neurologic is in outline form, and phenotypic markers could be fleshed out some more.

@evgenity How is the panel text coming along?
@rpill Looks like a good start to neurologic markers. Just need to turn it into a narrative.
@strygah How are age clocks and phenotyping going?

I’d like to shoot for getting these tasks completed in the next week. If you need more time, please let me know the timeline. If I do not hear from you before Thanksgiving, I’ll start finding other people to get the parts done.

@gustav_nilsonne and @moqri We will ping you when this gets into a more cohesive format. If either of you want more involvement, you’re welcome to dig in. Are either of you in the VitaDAO discord?

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Sounds good! Yes, I am in the VitaDao discord, generally I don’t manage to keep up with what’s going on there, but if you ping me there (@Song) I should get an e-mail notification. :slight_smile:

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@bowtiedshrike @evgenity @strygah Hey! Sorry for taking so long. I will finalize my first draft on neurologic markers by Monday, 28 Nov.

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Hello! I’m only halfway done with neurologic markers – biomarkers - Google Docs

The brain imaging part requires thorough reading, so it will take me some time to finalize. Will be done by mid-week.

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